Development of a multi-compartment population balance model for high-shear wet granulation with discrete element method
نویسندگان
چکیده
منابع مشابه
A multi-compartment population balance model for high shear granulation
This work extends the granulation model published by Braumann et al. (2007) (Chemical Engineering Science, 62, 4717-4728) to include multiple compartments in order to account for mixture heterogeneity encountered in powder mixing processes. A stochastic weighted algorithm is adapted to solve the granulation model which includes simultaneous coalescence and breakage. Then, a new numerical method...
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Scale-up studies on high shear wet granulation process from mini-scale to commercial scale.
A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...
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ژورنال
عنوان ژورنال: Computers & Chemical Engineering
سال: 2017
ISSN: 0098-1354
DOI: 10.1016/j.compchemeng.2017.01.022